IUPAC name: α-(5,6-dimethylbenzimidazolyl)cobamidcyanide
Bioavailability: readily absorbed in distal half of the ileum
Half-life: Approximately 6 days, (400 days in the liver)
CAS number: 68-19-9
Other names: cyano-5,6-dimethylbenzimidazole-cobalamin; Cyanocobalamin; VB12; 5,6-d
Mol. mass: 1355.37 g/mol
Vitamin B12 or vitamin B-12, also called cobalamin, is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production. It is red and most structurally complicated vitamin.
Vitamin B12 contains the biochemically rare element cobalt. Biosynthesis of the basic structure of the vitamin is only accomplished by bacteria, but conversion between different forms of the vitamin can be accomplished in the human body.
Different from other vitamins, cyanocobalamin,a common synthetic form of the vitamin, rarely occur in vegetables. In fact, it only occurs in laver and sea algae. However it is used in many pharmaceuticals and supplements, and as a food additive. That is because of its stability and lower cost.
Cobalamin helps oxidation of several compounds. CoA and the kreb cycle are also dependent on B12. It helps nerve cells, red blood cells, and the manufacturing/repair of DNA. It is vital for processing carbohydrates, proteins and fats, which help make all of the blood cells in our bodies. It also assists memory.
Lack of B12 results in anemia, constipation, heart disease, depression, weakness, neurological failures, permanent nerve damage, nausea, flatulence (gas), loss of appetite, confusion, weight loss, numbness/tingling in hands and feat, difficulty in maintaining balance, memory loss, and soreness of the mouth or tongue.
Vitamin B12 is used to treat vitamin B12 deficiency, cyanide poisoning, and hereditary deficiency of transcobalamin II. It is also given as part of the Schilling test for detecting pernicious anemia. High vitamin B12 level in elderly individuals may protect against brain atrophy or shrinkage, associated with Alzheimer's disease and impaired cognitive function.
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VB12 | Cobalamin | Maturation Factor | Redisol
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