Vitamin K3, Menadione

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Vitamin K3, Menadione

IUPAC name: 2-Methylnaphthalene-1,4-dione
CAS number: 58-27-5
Other names: Menaphthone; Vitamin K3; β-Methyl-1,4-naphthoquinone; 2-Methyl-1,4-naphthodione; 2-Methyl-1,4-naphthoquinone;Menadione (1.05793); Vitamin K2(0); Menadione; Vitamin K_3; 2-Methyl-1,4-dihydronaphthalene-1,4-dione
Molecular formula: C11H8O2
Molar mass: 172.18 g mol−1
Appearance: white power
Density: 1.225g/cm3
Melting point: 105–107 °C
Boiling point: 304.5 °C at 760mmHg
Solubility in water: Insoluble
Flash point: 113.8 °C

Vitamin K is a group of structurally similar vitamins. It is fat soluble and plays a critical role in blood clotting. It regulates blood calcium levels and activates at least 3 proteins involved in bone health. Menadione is a synthetic chemical compound sometimes used as a nutritional supplement because of its vitamin K activity. Low dose menadione is used as an inexpensive micronutrient for livestock. Forms of menadione are also included in some pet foods as a source of vitamin K. It is used in the treatment of Hypoprothrombinemia.

Vitamin K is an essential fat-soluble micronutrient, which is needed for a unique post-translational chemical modification in a small group of proteins with calcium-binding properties. Thus far, the unequivocal role of vitamin K in health is in the maintenance of normal coagulation. The vitamin Kdependent coagulation proteins are synthesized in the liver and comprise factors II, VII, IX, and X, which have a haemostatic role (i.e. they are procoagulants that arrest and prevent bleeding), and proteins C and S, which have an anticoagulant role (i.e. they inhibit the clotting process). Despite this duality of function, the overriding effect of nutritional vitamin K deficiency is a bleeding tendency caused by the relative inactivity of the procoagulant proteins. Vitamin K-dependent proteins synthesized by other tissues include the bone protein osteocalcin and matrix Gla protein, though their functions remain to be clarified.

Vitamin K should be stored in cool, ventilated place where it can be kept from water as well as light. Keep it in original package. Please use it in 12 months.

Related Names
Hemodal | Itykinone | Menadione Sodione Bisulfite | Coagulant

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